1991
ACTG 076
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Curators' Team
In April 1991, researchers began enrolling pregnant women with HIV in AIDS Clinical Trials Group protocol 076, a randomized, double blind, placebo controlled trial testing whether zidovudine, the drug described in AZT, could prevent the virus from passing from mother to child. The study was run with the National Institute of Allergy and Infectious Diseases and the National Institute of Child Health and Human Development. Women in the treatment group took the drug by mouth during pregnancy and by intravenous drip during labor, and their newborns received it by mouth for their first six weeks.
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ACTG 076
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LIVE LOUD
In April 1991, researchers began enrolling pregnant women with HIV in AIDS Clinical Trials Group protocol 076, a randomized, double blind, placebo controlled trial testing whether zidovudine, the drug described in AZT, could prevent the virus from passing from mother to child. The study was run with the National Institute of Allergy and Infectious Diseases and the National Institute of Child Health and Human Development. Women in the treatment group took the drug by mouth during pregnancy and by intravenous drip during labor, and their newborns received it by mouth for their first six weeks.
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1991
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2026
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NIAID
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Bethesda, MD
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1991
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ACTG 076
In April 1991, researchers began enrolling pregnant women with HIV in AIDS Clinical Trials Group protocol 076, a randomized, double blind, placebo controlled trial testing whether zidovudine, the drug described in AZT, could prevent the virus from passing from mother to child. The study was run with the National Institute of Allergy and Infectious Diseases and the National Institute of Child Health and Human Development. Women in the treatment group took the drug by mouth during pregnancy and by intravenous drip during labor, and their newborns received it by mouth for their first six weeks.
By December 20, 1993, the cutoff for the first analysis, 477 women had enrolled and 409 had given birth to 415 live infants, 363 of whose HIV status was known. On February 21, 1994, the two institutes announced the interim results. Among babies whose mothers received a placebo, an estimated 25.5 percent were infected by 18 months of age; among those in the zidovudine group, 8.3 percent were. Forty…