Saint Barbie is a painting by contemporary artist Mark Ryden, known for his pop surrealist style. The piece is a part of his The Meat Show series from the late 1990s, in which Ryden explores themes of innocence, commercialism, and the juxtaposition of the macabre with the whimsical. The art depicts the iconic Barbie doll in a context that blends the sacred with the profane. Barbie is portrayed with a halo, reminiscent of traditional Christian iconography of saints. This juxtaposition challenges the viewer to reconsider Barbie's cultural significance, which is often criticized for embodying superficial and materialistic ideals.

A collaboration with Mattel included the release of limited-edition Barbie dolls and related artwork, which blended Ryden's distinctive, whimsical, and often eerie aesthetics in Barbie form.